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From National Catholic Register:

An event on another day that month — Oct. 2, 1882 — that hastened the incurable physical and mental torments young Thérèse began to suffer. The problem began shortly she saw her sister Pauline enter the Carmelite monastery on that day. Pauline had been her second mother, raising her after their mother (now St.) Marie-Azelie died when Thérèse was only 4 years old. Constant headaches plagued Thérèse. These became more acute by winter. Worse followed. Shivering, convulsions, hallucinations, pains, lack of appetite. They subsided for one day, the day her sister Pauline received her habit at Carmel.


